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李娟 中级

作者:病原所时间:2017-12-11点击数:


2016/09-至今,泰山医学院,基础医学院,中级


教育背景:

2013/09-2016/07,扬州大学,预防兽医学专业,博士

2010/03-2013/07,中国动物卫生与流行病学中心国家外来动物疫病诊断中心,硕士(客座)

2010/09-2013/07,山东农业大学,基础病理学,硕士

2006/09-2010/07,山东农业大学,动物医学专业,本科


主要研究领域:

1、流感病毒的监测及分子流行病学分析;

2、肠道病毒的分子流行病学及致病机制研究;

3、抗寨卡病毒感染的药物筛选。


主持或参与的科研项目:

1. 泰山医学院2018年高层次课题培育计划项目,2018GCC01,长链非编码RNA-RP11-54O7.17下调干扰素刺激基因15ISG15)表达促进EV71感染致重症的机制研究,2019/01-2020/124万,在研,主持

2. 国家自然科学基金青年项目,81802009,长链非编码RNA BTF3P11调控细胞代谢促进肠道病毒71型复制机制的研究,2019/01-2021/1221万元,在研,参与

3. 国家自然科学基金面上项目,81871686,肠道细菌和中肠miRNA协同调控白纹伊蚊感染登革热病毒效率的机制研究,2019/01-2022/1257万元,在研,参与

4. 山东省自然科学基金,ZR201709280032,柯萨奇病毒A2型分子流行病学特征及对ICR鼠中枢神经系统的致病性研究,2018/03-2019/125万,在研,主持

5. “十三五”国家科技重大专项《艾滋病和病毒性肝炎等重大传染病防治》,2018ZX10101004-002,东非、中亚和东南亚等区域重要传染病防控关键保障技术研究—子课题2:中亚地区重要传染病防控保障技术研究,2018/01-2020/122438.99万,在研,参与

6. 泰安市科技发展计划,2017NS0107A组肠道病毒多重荧光Real-Time PCR精确诊断技术的研究,2018/01-2019/010.5万,在研,主持

7. 国家级大学生科技创新创业训练计划,201710439022,手足口病柯萨奇A2病毒新分离株对ICR乳鼠的感染性研究,2017/09-2018/091.0万,在研,指导教师

8. 山东省中医药科技发展计划,2017-248,丹参酚酸B抗寨卡病毒作用机理的研究初探,2017/07-2020/072万,在研,主持

9. “十三五”国家科技重大专项《艾滋病和病毒性肝炎等重大传染病防治》,2017ZX10104001-006,基于全基因组的病毒网络化监测和溯源技术体系研究—子课题6:基于病毒全基因组的网络化监测与暴发发现网络化在线分析系统的构建,2017/01-2020/12529.51万,在研,参与


发表文章:

1. Juan Li#, Chuansong Quan#, Yun Xie#, Changwen Ke, Yifei Nie, Quanjiao Chen, Tao Hu, Jianjun Chen, Gary Wong, Qianli Wang, Luzhao Feng, Hongjie Yu, Yingxia Liu, Wenjun Liu, George F. Gao, William J. Liu, Weifeng Shi*, Yuhai Bi*, Continued reassortment of avian H6 influenza viruses from Southern China, 2014-2016, Transbound Emerg Dis, 2019, 66(1): 592-598.

2. Li J, Gu M, Liu D, Liu B, Jiang K, Zhong L, Liu K, Sun W, Hu J, Wang X, Hu S, Liu X, Liu X*. Phylogenetic and Biological Characterization of Three K1203 (H5N8) - like Avian Influenza A Reassortants in China in 2014. Arch Virol. 161(2): 289-302, 2016.

3. Li J, Gu M, Liu K, Gao R, Liu D, Sun W, Hu J, Wang X, Liu X, Liu X*, Biological characterization of clade 2.3.4.4 H5Nx subtype avian influenza viruses, the XXV World’s Poultry Congress (WPC2016), Beijing, P.R. China, 2016.

4. Li YB, Li J, Wang ZL, Liu SD. Study on Hsp90 expression in different tissues and its antibody in serum of chickens infected with Marek’s diseases. Journal of Integrative Agriculture. 13(6): 1355-1362, 2014. (Co-author)

5. Duan Z, Li J, Zhu J, Chen J, Xu H, Wang Y, Liu H, Hu S, Liu X*. A single amino acid mutation, R42A, in the Newcastle disease virus matrix protein abrogates its nuclear localization and attenuates viral replication and pathogenicity. Journal of General Virology. 95: 1067–1073, 2014.

6. Zhang Z, Dong Z, Li J, Carr MJ, Zhuang D, Wang J, Zhang Y, Ding S, Tong Y, Li D, Shi W.  Protective Efficacies of Formaldehyde-Inactivated Whole-Virus Vaccine and Antivirals in a Murine Model of Coxsackievirus A10 Infection. J. Virol. 91. 2017.

7. Liu J, Zhu J, Xu H, Li J, Hu Z, Hu S, Wang X, Liu X. Effects of the HN Antigenic Difference between the Vaccine Strain and the Challenge Strain of Newcastle Disease Virus on Virus Shedding and Transmission. Viruses 9:225. 2017.

8. Zhang Z, Dong Z, Wei Q, Carr MJ, Li J, Ding S, Tong Y, Li D, Shi W. A Neonatal Murine Model of Coxsackievirus A6 Infection for Evaluation of Antiviral and Vaccine Efficacy. J. Virol. 91. 2017.

9. Lv Q, Zhang H, Tian L, Zhang R, Zhang Z, Li J, Tong Y, Fan H, Carr MJ, Shi W. Novel sub-lineages, recombinants and reassortants of severe fever with thrombocytopenia syndrome virus. Ticks Tick Borne Dis. 8:385-390. 2017.

10. Liu D, Zhang Z, He L, Gao Z, Li J, Gu M, Hu J, Wang X, Liu X, Liu X. Characteristics of the emerging chicken-origin highly pathogenic H7N9 viruses: A new threat to public health and poultry industry. J. Infect. 2017.

11. Hao X, Wang J, Hu J, Lu X, Gao Z, Liu D, Li J, Wang X, Gu M, Hu Z, Liu X, Hu S, Xu X, Peng D, Jiao X, Liu X. Internal Gene Cassette from a Genotype S H9N2 Avian Influenza Virus Attenuates the Pathogenicity of H5 Viruses in Chickens and Mice. Frontiers in microbiology 8:1978. 2017.


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